­
­
­
­

Inventi Impact: Med Chem

Articles

  • Inventi:pmc/115399/26
    An Analogue of Indapamide: Crystal Structure and Hirshfeld Surface Analysis of 3-Chloro-4-(N,N-Diethynylsulfamoyl)- N-(2-Methylindolin-1-Yl)-Benzamide
    01-Oct-2026 Research 2026 : October-December
    Youssef Ramli, Wedad Al Garadi, El Mokhtar Essassi, Camille Kalonji Mubengayi, Abdulsalam Alsubarid, Joel T Mague

    The title mol­ecule, C22H20ClN3O3S, adopts a shallow cup-shaped conformation with the chloro­benzamide portion as the bottom. A puckering analysis of the five-membered ring indicates an envelope conformation. In the crystal, helical chains along the a-axis direction are formed by N—H⋯O hydrogen bonds reinforced by C—H⋯π(ring) and weak π-stacking inter­actions. No directed inter­actions between chains appear to exist. A Hirshfeld surface analysis was performed.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Ramli, Youssef, et al. "An analogue of indapamide: crystal structure and Hirshfeld surface analysis of 3- chloro-4-(N, N-diethynylsulfamoyl)-N-(2-methylindolin-1-yl) benzamide." Structure Reports 82.5 (2026). https://doi.org/10.1107/S2056989026003580 http://creativecommons.org/licenses/by/4.0/ Some formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
    Download Full Text